{"id":12001,"date":"2017-08-22T11:30:00","date_gmt":"2017-08-22T11:30:00","guid":{"rendered":"http:\/\/contenidosportal.sld.cu\/portal20142020\/?p=2487"},"modified":"2017-08-22T11:30:00","modified_gmt":"2017-08-22T11:30:00","slug":"direct-detection-early-stage-cancers-using-circulating-tumor-dna","status":"publish","type":"post","link":"https:\/\/contenidosportal.sld.cu\/portal20142020\/2017\/08\/22\/direct-detection-early-stage-cancers-using-circulating-tumor-dna\/","title":{"rendered":"Direct detection of early-stage cancers using circulating tumor DNA"},"content":{"rendered":"<div class=\"item-node\">\n<p><a href=\"http:\/\/stm.sciencemag.org\/content\/9\/403\/eaan2415.full\" target=\"_blank\" rel=\"noopener\">Direct detection of early-stage cancers using circulating tumor DNA <\/a><br \/>\nPhallen J, Sausen M, Adleff V,&nbsp; Leal A,&nbsp; Hruban C,&nbsp; White J, y cols. <em>Science Translational Medicine<\/em>&nbsp; 16 Agosto 2017:9(4033), eaan2415. DOI: 10.1126\/scitranslmed.aan2415<\/p>\n<p>La detecci&oacute;n y el an&aacute;lisis del ADN libre de c&eacute;lulas presente en la sangre de pacientes es cada vez m&aacute;s aceptado en el campo de la oncolog&iacute;a.<\/p>\n<p>Si bien este m&eacute;todo se aplica en general en el monitoreo de pacientes aquejados de tumores, no resulta &uacute;til en el diagn&oacute;stico precoz del c&aacute;ncer debido a su insuficiente sensibilidad para detectar tumores muy peque&ntilde;os que solo vierten min&uacute;sculas cantidades de ADN en la sangre, y a las dificultades encontradas a la hora de identificar cambios gen&eacute;ticos asociados al c&aacute;ncer sin conocer las mutaciones presentes en el tumor primario.<\/p>\n<p>Phallen y colaboradores desarrollaron un m&eacute;todo denominado secuenciaci&oacute;n de la correcci&oacute;n de errores identificados (targeted error correction sequencing) que resuelve las limitaciones mencionadas y muestra la factibilidad de la detecci&oacute;n del ADN circulante libre de c&eacute;lulas&nbsp; proveniente de tumores en fase temprana, todo lo cual muestra las potencialidades del m&eacute;todo para su utilizaci&oacute;n en la detecci&oacute;n del c&aacute;ncer.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Direct detection of early-stage cancers using circulating tumor DNA Phallen J, Sausen M, Adleff V,&nbsp; Leal A,&nbsp; Hruban C,&nbsp; White J, y cols. Science Translational Medicine&nbsp; 16 Agosto 2017:9(4033), eaan2415. DOI: 10.1126\/scitranslmed.aan2415 La detecci&oacute;n y el an&aacute;lisis del ADN libre de c&eacute;lulas presente en la sangre de pacientes es cada vez m&aacute;s aceptado en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-12001","post","type-post","status-publish","format-standard","hentry","category-noticia"],"_links":{"self":[{"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/posts\/12001","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/comments?post=12001"}],"version-history":[{"count":0,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/posts\/12001\/revisions"}],"wp:attachment":[{"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/media?parent=12001"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/categories?post=12001"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/tags?post=12001"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}