{"id":11614,"date":"2016-05-15T09:04:07","date_gmt":"2016-05-15T09:04:07","guid":{"rendered":"http:\/\/contenidosportal.sld.cu\/portal20142020\/?p=1430"},"modified":"2016-05-15T09:04:07","modified_gmt":"2016-05-15T09:04:07","slug":"zika-virus-infection-during-pregnancy-mice-causes-placental-damage-and-fetal-demi","status":"publish","type":"post","link":"https:\/\/contenidosportal.sld.cu\/portal20142020\/2016\/05\/15\/zika-virus-infection-during-pregnancy-mice-causes-placental-damage-and-fetal-demi\/","title":{"rendered":"Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise"},"content":{"rendered":"<div class=\"item-node\">\n<p><a href=\"http:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(16)30556-6\" target=\"_blank\" rel=\"noopener\">Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise<\/a><br \/>\nMiner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU y Diamond MS<br \/>\nCell. Mayo 2016. DOI: http:\/\/dx.doi.org\/10.1016\/j.cell.2016.05.008<\/p>\n<p>La infecci&oacute;n por virus zika (ZIKV, siglas en ingl&eacute;s) en mujeres embarazadas produce disminuci&oacute;n del crecimiento fetal intrauterino, aborto espont&aacute;neo y microcefalia.<\/p>\n<p>En el presente art&iacute;culo se describen dos modelos obtenidos en ratones, con enfermedad placentaria y fetal asociados a la trasmisi&oacute;n in &uacute;tero de ZIKV.<\/p>\n<p>Los ratones hembra, que carecen del tipo I de se&ntilde;al de interfer&oacute;n (Ifnar1-\/-), se cruzaron con machos tipo salvaje (WT, siglas en ingl&eacute;s), para producir fetos heterocig&oacute;ticos que semejan el estado inmune de los fetos humanos.<\/p>\n<p>Al inocular con el virus a las madres, en el d&iacute;a embrionario 6.5 (E6.5) o E7.5, se produjo la muerte fetal, la que est&aacute; asociada a la infecci&oacute;n con ZIKV de la placenta y del cerebro del feto. Se identificaron ZIKV dentro de los trofoblastos le la placenta materna y fetal, lo que es consistente con que la v&iacute;a de infecci&oacute;n es transplacentaria.<\/p>\n<p>El bloqueo de los anticuerpos de la se&ntilde;alizaci&oacute;n Ifnar1 en ratones WT embarazadas elev&oacute; la infecci&oacute;n transplacentaria con ZIKV aunque no produjo muerte fetal.<\/p>\n<p>Estos modelos facilitar&aacute;n el estudio de la patog&eacute;nesis de la ZIKV, de la trasmisi&oacute;n in &uacute;tero, y tambi&eacute;n del estudio de tratamientos y vacunas para prevenir las malformaciones cong&eacute;nitas.<\/p>\n<p><a href=\"http:\/\/www.cell.com\/cell\/pdf\/S0092-8674(16)30556-6.pdf\" target=\"_blank\" rel=\"noopener\">Descargar el art&iacute;culo completo en pdf <\/a><\/p>\n<\/div>\n<div class=\"clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU y Diamond MS Cell. Mayo 2016. DOI: http:\/\/dx.doi.org\/10.1016\/j.cell.2016.05.008 La infecci&oacute;n por virus zika (ZIKV, siglas en ingl&eacute;s) en mujeres embarazadas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-11614","post","type-post","status-publish","format-standard","hentry","category-noticia"],"_links":{"self":[{"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/posts\/11614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/comments?post=11614"}],"version-history":[{"count":0,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/posts\/11614\/revisions"}],"wp:attachment":[{"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/media?parent=11614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/categories?post=11614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/contenidosportal.sld.cu\/portal20142020\/wp-json\/wp\/v2\/tags?post=11614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}